The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.
Moon EJ, Mello SS, Li CG, Chi JT, Thakkar K, Kirkland JG, Lagory EL, Lee IJ, Diep AN, Miao Y, Rafat M, Vilalta M, Castellini L, Krieg AJ, Graves EE, Attardi LD, Giaccia AJ.
Moon EJ, et al.
Nat Commun. 2021 Jul 14;12(1):4308. doi: 10.1038/s41467-021-24631-6.
Nat Commun. 2021.
PMID: 34262028
Free PMC article.
In this study, we identify v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) as a potent regulator of tumor invasion without affecting cell viability. ...
In this study, we identify v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) as a potent regulator of tumor invasion wi …